Table 2. Spatial Coordinates and Statistics of the Clusters Identified in the Voxel-Wise [¹¹C]-FLB-457 BP_ND Abstinence>Smoking, n=10.

Region	Number of voxels	Brodmann	Peak coordinates (MNI space)			Peak t	Peak p
			x	y	z
Medial cluster	1331						0.013 (cluster level)
Cingulate gyrus		24	4	10	42	5.32	<0.001a
		32	6	14	42	4.51	0.002
		31	−12	−30	46	3.55	0.003
Anterior cingulate		32	2	38	16	2.93	0.008
		24	6	42	−4	2.32	0.022
Medial frontal gyrus (Med. FG)		6	−6	−6	50	3.83	0.002
		9	10	52	22	3.47	0.004
		8	8	30	44	2.27	0.024
Superior frontal gyrus		6	14	38	48	3.17	0.006
		9	12	56	22	3.08	0.007
		8	8	46	42	1.99	0.038
Precuneus		7	−6	−28	50	3.90	0.002
L ACC/Med. FG	148	10/9/32	−10	48	16	3.45	0.004
R PFC/middle frontal gyrus (MFG)	323	9	38	34	26	3.38	0.004
		8	30	32	36	2.47	0.018
L PFC cluster	612						0.075 (cluster-level)
Precentral gyrus		4	−26	−16	60	3.84	0.002
MFG		8	−28	24	48	3.57	0.003
		10	−36	48	20	2.76	0.011
		6	−18	8	64	2.69	0.012
		9	−26	44	30	2.21	0.027
L MFG/precentral gyrus	88	6	−44	2	34	2.50	0.017
		4	−50	−2	44	2.24	0.026
L amygdala/uncus	76		−24	0	−30	3.28	0.005
R amygdala/uncus	98		26	−4	−30	3.03	0.007
L insula	58		−40	−12	4	2.54	0.016

Abbreviations: ACC, anterior cingulate cortex; BP_ND, binding potential; FDR, false discovery rate; PFC, prefrontal cortex; Med. FG, medial frontal gyrus; MFG, middle frontal gyrus; R, right; L, left.

Uncorrected P-values.

^aSurvived FDR correction for multiple comparisons at p<0.01.