Table 2. Group Comparisons of Mean Diffusion Metrix of Each ROI.
| White matter tract |
Male |
Female |
rs2070045 F(p)a | sex F(p)a | rs2070045 × sex F(p)a | ||||
|---|---|---|---|---|---|---|---|---|---|
| G/G (N=19) | G/T (N=24) | T/T (N=18) | G/G (N=24) | G/T (N=25) | T/T (N=16) | ||||
| FA | |||||||||
| Cingulum_R. | 0.36±0.03 | 0.37±0.02 | 0.35±0.03 | 0.37±0.03 | 0.37±0.03 | 0.37±0.03 | 0.39 (0.68) | 2.85 (0.094) | 0.39 (0.68) |
| Cingulum_l. | 0.37±0.03 | 0.37±0.02 | 0.36±0.02 | 0.37±0.03 | 0.38±0.03 | 0.38±0.03 | 0.31 (0.74) | 3.75 (0.055) | 0.65 (0.53) |
| Cingulum_ hippocampus_R. | 0.31±0.02 | 0.31±0.03 | 0.31±0.03 | 0.32±0.03 | 0.34±0.03 | 0.33±0.02 | 0.20 (0.82) | 14.36 (<0.001)* | 1.10 (0.34) |
| Cingulum_ hippocampus_l. | 0.30±0.02 | 0.30±0.03 | 0.31±0.03 | 0.32±0.03 | 0.33±0.03 | 0.32±0.03 | 0.040 (0.96) | 14.25 (<0.001)* | 1.15 (0.32) |
| MD ( × 10-4) | |||||||||
| Cingulum_R. | 7.78±0.36 | 7.70±0.36 | 7.90±0.39 | 7.67±0.35 | 7.80±0.32 | 7.74±0.23 | 1.57 (0.21) | 0.24 (0.62) | 3.02 (0.053) |
| Cingulum_l. | 7.96±0.28 | 7.93±0.30 | 8.05±0.23 | 7.85±0.39 | 7.93±0.30 | 7.97±0.28 | 2.42 (0.09) | 0.00 (1.00) | 1.26 (0.29) |
| Cingulum_ hippocampus_R. | 9.19±0.91 | 8.75±0.64 | 8.99±0.77 | 8.68±0.66 | 8.56±0.56 | 8.55±0.50 | 2.00 (0.14) | 3.61 (0.060) | 1.17 (0.32) |
| Cingulum_ hippocampus_l. | 9.58±1.20 | 8.93±0.53 | 9.18±0.77 | 8.71±0.62 | 8.79±0.80 | 9.01±0.64 | 2.28 (0.11) | 2.28 (0.13) | 5.09 (0.008)* |
| DA ( × 10-4) | |||||||||
| Cingulum_R. | 10.87±0.37 | 10.83±0.42 | 10.97±0.36 | 10.82±0.35 | 11.01±0.41 | 10.98±0.34 | 1.64 (0.20) | 3.07 (0.082) | 1.74 (0.18) |
| Cingulum_l. | 11.34±0.29 | 11.28±0.38 | 11.34±0.37 | 11.22±0.36 | 11.38±0.33 | 11.45±0.34 | 1.43 (0.25) | 1.72 (0.19) | 2.40 (0.096) |
| Cingulum_ hippocampus_R. | 12.07±0.93 | 11.53±0.59 | 11.84±0.80 | 11.63±0.62 | 11.63±0.51 | 11.53±0.49 | 2.00 (0.14) | 0.32 (0.57) | 2.67 (0.07) |
| Cingulum_ hippocampus_l. | 12.38±1.23 | 11.65±0.51 | 12.02±0.70 | 11.63±0.56 | 11.78±0.77 | 11.92±0.56 | 2.66 (0.075) | 0.12 (0.73) | 5.98 (0.003)* |
| DR ( × 10-4) | |||||||||
| Cingulum_R. | 6.23±0.41 | 6.14±0.41 | 6.35±0.46 | 6.11±0.43 | 6.19±0.36 | 6.14±0.31 | 0.59 (0.56) | 1.12 (0.29) | 0.76 (0.47) |
| Cingulum_l. | 6.27±0.36 | 6.27±0.36 | 6.39±0.26 | 6.18±0.46 | 6.21±0.36 | 6.24±0.37 | 0.69 (0.50) | 2.20 (0.14) | 0.093 (0.91) |
| Cingulum_ hippocampus_R. | 7.75±0.91 | 7.56±1.19 | 7.53±0.80 | 7.19±0.71 | 7.06±0.65 | 7.10±0.56 | 0.31 (0.74) | 8.91 (0.003)* | 0.068 (0.93) |
| Cingulum_ hippocampus_l. | 8.18±1.18 | 7.75±1.16 | 7.73±0.86 | 7.27±0.67 | 7.34±0.82 | 7.52±0.70 | 0.30 (0.74) | 8.76 (0.004)* | 1.28 (0.28) |
Abbreviations: DA, axial diffusivity; DR, radial diffusivity; FA, fractional anisotropy; MD, mean diffusivity. Note: data expressed as mean±SD. P-values are all raw P-values. *P<0.05 significant after Bonferroni correction.
a
Multivariate analysis of variance (MANOVA) was used to determine the main effect of the genotype and sex on the DTI indices, as well as the interaction between them (age, education, and APOEɛ4 as covariates).