Table 1.
Genetic alterations in MALT lymphomas.
| Name | Type | Affected gene | NF-κB activation | Subtype of MALT lymphoma mainly involved |
|---|---|---|---|---|
| t(1;14)(p22,q32) | Translocation | BCL10 | Yes | Stomach, lung, and skin |
| t(11;18)(q21,q21) | Translocation | BIRC2, MALT1 | Yes | Pulmonary, gastric |
| t(14;18)(q32,q21) | Translocation | MALT1 | Yes | Ocular adnexa, orbit, skin, and salivary glands |
| t(3;14)(p14.1,q32) | Translocation | FOXP1 | No | |
|
| ||||
| Trisomy 3 | Trisomy |
FOXP1*
BCL6* |
No No |
Gastrointestinal |
| Trisomy 12 | Trisomy | Unknown | No | |
| Trisomy 18 | Trisomy | Unknown | No | |
|
| ||||
| TNFAIP3 | Deletion | TNFAIP3 | Yes | Ocular adnexal, salivary gland, thyroid, and liver |
|
| ||||
| PIM1 | Mutation | PIM1 | No | Gastric, extragastric |
| cMyc | Mutation | cMyc | No | Gastric, extragastric |
| P53 | Mutation | P53 | No | |
| Myd88 | Mutation | Myd88 | Yes | Ocular adnexal |
|
| ||||
| P16 | Hypermethylation | P16 | No | |
| P57 | Hypermethylation | P57 | No | |
| TNFAIP3 | Hypermethylation | TNFAIP3 | No | Ocular adnexal, salivary, and thyroidal glands |
*The two potentially affected genes.