Table 2. Clinicopathologic Characteristics of Invasive Lobular Carcinoma.
| Parameters | Total, n=114 (%) | Classic type, n=102 (%) | Pleomorphic type, n=12 (%) | p value |
|---|---|---|---|---|
| Age (yrs) | 0.033 | |||
| <50 | 63 (55.3) | 60 (58.8) | 3 (25.0) | |
| ≥50 | 51 (44.7) | 42 (41.2) | 9 (75.0) | |
| Nuclear grade | <0.001 | |||
| 1/2 | 102 (89.5) | 102 (100.0) | 0 (0.0) | |
| 3 | 12 (10.5) | 0 (0.0) | 12 (100.0) | |
| Histologic grade | <0.001 | |||
| I/II | 109 (95.6) | 102 (100.0) | 7 (58.3) | |
| III | 5 (4.4) | 0 (0.0) | 5 (41.7) | |
| T stage | 0.026 | |||
| T1 | 67 (58.8) | 64 (62.7) | 3 (25.0) | |
| T2/T3 | 47 (41.2) | 38 (37.3) | 9 (75.0) | |
| Lymph node metastasis | 0.749 | |||
| Absent | 80 (70.2) | 72 (70.6) | 8 (66.7) | |
| Present | 34 (29.8) | 30 (29.4) | 4 (33.3) | |
| ER | 0.158 | |||
| Negative | 7 (6.1) | 5 (4.9) | 2 (16.7) | |
| Positive | 107 (93.9) | 97 (95.1) | 10 (83.3) | |
| PR | 0.005 | |||
| Negative | 19 (16.7) | 13 (12.7) | 6 (50.0) | |
| Positive | 95 (83.3) | 89 (87.3) | 6 (50.0) | |
| HER-2 | 0.002 | |||
| Negative | 107 (93.9) | 99 (97.1) | 8 (66.7) | |
| Positive | 7 (6.1) | 3 (2.9) | 4 (33.3) | |
| AR | 0.515 | |||
| Negative | 48 (42.1) | 44 (43.1) | 4 (33.3) | |
| Positive | 66 (57.9) | 58 (56.9) | 8 (66.7) | |
| Ki-67 LI | <0.001 | |||
| ≤14 | 92 (80.7) | 88 (86.3) | 4 (33.3) | |
| >14 | 22 (19.3) | 14 (13.7) | 8 (66.7) | |
| Molecular type | <0.001 | |||
| Luminal A | 86 (75.4) | 83 (81.4) | 3 (25.0) | |
| Luminal B | 22 (19.3) | 15 (14.7) | 7 (58.3) | |
| HER-2 | 1 (0.9) | 0 (0.0) | 1 (8.3) | |
| TNBC | 5 (4.4) | 4 (3.9) | 1 (8.3) |
ER, estrogen receptor; PR, progesterone receptor; AR, androgen receptor; LI, labeling index; HER-2, human epidermal growth factor receptor-2; TNBC, triple-negative breast cancer.