Table 4. Expressions of Sarcosine Metabolism-Related Proteins in Normal Breast Tissue and ILC.
| Parameters | Total, n=114 (%) | Normal tissue, n=30 (%) | ILC | p value† | ||
|---|---|---|---|---|---|---|
| Classic type, n=102 (%) | Pleomorphic type, n=12 (%) | p value* | ||||
| GNMT | 0.349 | 0.345 | ||||
| Negative | 107 (93.9) | 30 (100.0) | 95 (93.1) | 12 (100.0) | ||
| Positive | 7 (6.1) | 0 (0.0) | 7 (6.9) | 0 (0.0) | ||
| SARDH | 0.473 | 0.014 | ||||
| Negative | 94 (82.5) | 30 (100.0) | 85 (83.3) | 9 (75.0) | ||
| Positive | 20 (17.5) | 0 (0.0) | 17 (16.7) | 3 (25.0) | ||
| PIPOX | 0.714 | <0.001 | ||||
| Negative | 42 (36.8) | 28 (93.3) | 37 (36.3) | 5 (41.7) | ||
| Positive | 72 (63.2) | 2 (6.7) | 65 (63.7) | 7 (58.3) | ||
| Sarcosine metabolic type | 0.829 | <0.001 | ||||
| High sarcosine type | 1 (0.9) | 0 (0.0) | 1 (1.0) | 0 (0.0) | ||
| Intermediate sarcosine type | 6 (5.3) | 0 (0.0) | 6 (5.9) | 0 (0.0) | ||
| Low sarcosine type | 70 (61.4) | 2 (6.7) | 62 (60.8) | 8 (66.7) | ||
| Null type | 37 (32.5) | 28 (93.3) | 33 (32.4) | 4 (33.3) | ||
ILC, invasive lobular carcinoma; GNMT, glycine N-methyltransferase; SARDH, sarcosine dehydrogenase; PIPOX, l-pipecolic acid oxidase.
*Compared between classic type and pleomorphic type.
†Compared between normal tissue and ILC.