Table 3. Comparison of Areas Under the ROC Curves (95% CI) for Potential Markers of Insulin Resistance (HOMA-IR≥2.5) of Subjects Categorized by Body Mass Index.
| Characteristics | AUC (95% CI) | |||||
|---|---|---|---|---|---|---|
| Total | Non-obese (<25.0 kg/m2) | Obese (≥25.0 kg/m2) | ||||
| n=458 | p value | n=352 | p value | n=106 | p value | |
| ALT (IU/L) | 0.587 (0.52-0.64) | 0.003 | 0.527 (0.45-0.60) | 0.484 | 0.623 (0.51-0.73) | 0.039 |
| AST (IU/L) | 0.662 (0.60-0.72) | <0.001 | 0.518 (0.44-0.59) | 0.643 | 0.746 (0.64-0.84) | <0.001 |
| ALT/AST ratio | 0.348 (0.29-0.40) | <0.001 | 0.498 (0.42-0.56) | 0.963 | 0.219 (0.13-0.30) | <0.001 |
| TC (mg/dL) | 0.576 (0.52-0.63) | 0.010 | 0.473 (0.10-0.54) | 0.494 | 0.670 (0.56-0.77) | 0.004 |
| TG (mg/dL) | 0.742 (0.68-0.79) | <0.001 | 0.617 (0.53-0.69) | 0.003 | 0.837 (0.76-0.91) | <0.001 |
| HDL-C (mg/dL) | 0.297 (0.24-0.35) | <0.001 | 0.413 (0.33-0.49) | 0.033 | 0.266 (0.16-0.36) | <0.001 |
| LDL-C (mg/dL) | 0.620 (0.56-0.67) | <0.001 | 0.494 (0.41-0.57) | 0.879 | 0.698 (0.58-0.80) | 0.001 |
| hs-CRP (mg/dL) | 0.724 (0.67-0.77) | <0.001 | 0.610 (0.52-0.69) | 0.006 | 0.734 (0.63-0.83) | <0.001 |
ROC, receiver operating characteristics; CI, confidence interval; AUC, area under ROC curve; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; hs-CRP, high sensitivity C-reactive protein; HOMA-IR, homeostasis model assessment of insulin resistance.
Data for ALT, AST, ALT/AST ratio, LDL-C, TG were skewed and log-transformed for analysis.