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Effects of antiresistin RNA oligo on mRNA expression. (a) TNF-α, IL-6, leptin, and adiponectin mRNA expression in adipose tissue; (b) hepatic mRNA expression of TNF-α, IL-6, PEPCK, and SREBP-1c in chow fed mice and HFD fed mice treated with a control oligo or antiresistin oligo. Data are mean ± SE (n = 10). a P < 0.05 and b P < 0.01 versus chow fed mice; d P < 0.05 versus HFD-Con-oligo mice.
