Table 3.
Selection for Resistance to the Diphenyl Ether saFabI Inhibitors
| Mutants derived from S. aureus N315 |
Selections for mutants resistant to compound |
fabI gene |
|
|---|---|---|---|
| Nucleotide changes a | Amino acid changes | ||
| N315Tr.4 | Triclosan | GCA → GTA | Ala95 → Val |
| N315Tr.5 | Triclosan | GCA → GTA | Ala95 → Val |
| N315PT01.1 | EPP | GCA → GTA | Ala95 → Val |
| N315PT01.2 | EPP | GCA → GTA | Ala95 → Val |
| N315PT01.3 | EPP | GCA → GTA | Ala95 → Val |
| N315PT01.4 | EPP | GCA → GTA | Ala95 → Val |
| N315PT52.1 | CPP | ATC → AGC | Ile 193 → Ser |
| N315PT52.2 | CPP | TTC → TCC | Phe204 → Ser |
| N315PT52.3 | CPP | TTC → TCC | Phe204 → Ser |
| N315PT52.4 | CPP | TTC → TCC | Phe204 → Ser |
a
Mutation sites are shown in underline.