Table 3.

Proteins decreased in content in pre-retinopathic RPE.

Average ratio DM/Ctrla	P valueb	Spot No.c	Protein name	Accession number (Swiss- Protd)	Sequence Coverage (%)	Mascot score [p value]	Theoretical MW (Da) [pI]e	Observed MW (Da) [pI]f	MS/MS Peptides (#)	Function (Swiss-Prot/ PubMedd)	Altered expression in DMg
0.53	0.006	16	Gamma enolase	P09104	40	106 [3.9E-07]	47239 [4.91]	47000 [5.2]	2	Energy metabolism	22
0.58	0.026	17	Phosphoglycerate mutase 1	P18669	47	82 [9.40E-05]	28900 [6.67]	28000 [7.5]	2	Energy metabolism	26
0.64	0.038	18	Succinyl CoA: 3-ketoacid coenzyme A	P55809	22	56 [0.040]	56122 [7.14]	58000 [7.5]	1	Energy metabolism	49

^aNormalized intensity values averaged for the identified protein spots are calculated as a ratio (Diabetes/Control)

^bResults from Student’s t test comparison of diabetic and control samples

^cSpot numbers correspond to numbers used in Figures 1 and 2

^dDatabases containing protein sequence information and journal citations

^eTheoretical molecular weight (MW) in Daltons (Da) and isoelectric point (pI)

^fObserved approximate molecular weight (MW) in Daltons (Da) and isoelectric point (pI)

^gProteins previously reported to be associated with diabetes in tissues other than RPE.