Table 2.

Overview of SENP inhibitors identified using virtual screening.

SENP target	Structure of representative compounds	Activity of most potent compounds	Virtual screening method used	Reference
SENP1		Compound 9 IC50 = 2.38 μM Compound 10 IC50 = 1.08 μM	Molecular docking of 180,000 compound library using Glide program.	Chen et al. [70]
SENP1, SENP2, SENP7		Compound 11 SENP1 IC50 = 5.9 μM SENP2 IC50 = 2.9 μM SENP7 IC50 = 3.5 μM Compound 12 SENP1 IC50 = 2.1 μM SENP2 IC50 = 2.0 μM SENP2 IC50 = 2.7 μM	Molecular docking of 250,000 compound library using Glide program.	Madu et al. [71]
SENP1, SENP2		Compound 13 SENP1 IC50 = 9.7 μM SENP2 IC50 = 5.9 μM Compound 14 SENP1 IC50 = > 30 μM SENP2 IC50 = 3.7 μM	Hierarchical virtual screening of ~ 4 million compound library by shape and electrostatic similarity search using ROCS and EON program. Molecular docking using Glide program prioritized hits for bioassay.	Kumar et al. [72]
SENP1		Compound 15 IC50 = 1.29 μM	Molecular docking of 100,000 compound library using Dock and Autodock program.	Wen et al. [73]