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. 2015 Apr 15;35(15):5969–5982. doi: 10.1523/JNEUROSCI.4668-14.2015

Figure 1.

Figure 1.

Expression of immune-related genes from whole-brain lysates. Average values and SEM for the relative change in mRNA levels are shown for immune-related genes from whole-brain lysate samples from CVN-AD, mNos2−/−, WT (C57BL/6), and APPSwDI mice. A–D, Genes that were upregulated in CVN-AD mice before 36 weeks of age. E–I, Genes that were upregulated in CVN-AD mice at or after 36 weeks of age. J–L, Gene expression of chemokine receptors. mRNA expression was measured using quantitative RT-PCR and represent the 2(−delta delta C(T)) compared with WT mice. Samples were analyzed by two-way ANOVA and post hoc multiple comparison test with Bonferonni's correction. *Comparisons between CVN-AD or APPSwDI and WT. #Comparisons between CVN-AD and APPSwDI mice. *p < 0.05. **p < 0.01. ***p < 0.001. ****p < 0.0001. #p < 0.05. ##p < 0.01. ###p < 0.001. ####p < 0.0001. n > 5 mice per group.