Table 3.
Resting-state functional connectivity results: total PCL-R and factor scores
| Seed | Brain region | MNI coordinates | Cluster size (voxels), t value |
|---|---|---|---|
| Regression results: main cortical networks of interest | |||
| DMN | |||
| Factor 1 | |||
| PCC | Right superior frontal gyrus | 32, 18, 51 | 107, −4.07 |
| L IPL | Left superior frontal gyrus | −25, 12, 54 | 127, −4.50 |
| R IPL | Left posterior cingulate | −7, −36, 30 | 149, −4.24 |
| Factor 2 | |||
| mPFC | Left dorsomedial prefrontal | −4, 30, 24 | 268, 4.54 |
| mPFC | Left superior frontal gyrus | −16, 12, 63 | 167, 4.26 |
| mPFC | Right posterior cingulate | 5, −27, 30 | 115, 4.42 |
| mPFC | Left precuneus | −1, −75, 33 | 80, 3.75 |
| PCC | Left dorsomedial PFC | −7, 36, 51 | 124, 4.18 |
| PCC | Left superior frontal gyrus extending to middle frontal gyrus | −28, 12, 60 | 84, 4.23 |
| FPN | |||
| Total PCL-R | |||
| R IPS | Bilateral dorsal anterior cingulate | 2, 6, 42 | 103, −4.22 |
| R IPS | Right precuneus | 17, −78, 48 | 74, −4.17 |
| Factor 1 | |||
| L IPS | Right superior frontal gyrus | 26, 54, 27 | 81, −4.41 |
| R IPS | Left precuneus | −13, −78, 51 | 157, −4.91 |
| L dlPFC | Left superior parietal lobule | −37, −54, 48 | 76, −3.94 |
| Factor 2 | |||
| L dlPFC | Right middle frontal gyrus | 44, 36, 24 | 73, 4.66 |
| L dlPFC | Right supramarginal gyrus | 53, −39, 45 | 73, 3.79 |
| CON | |||
| Factor 1 | |||
| L aIfO | Right dACC/msFC | 5, 0, 66 | 261, −4.95 |
| L aIfO | Right anterior insula | 38, 21, −6 | 103, −3.64 |
| L aIfO | Left supramarginal gyrus | −52, −33, 21 | 82, −4.36 |
| R aIfO | Right dorsal anterior cingulate (cluster extends bilaterally) | 5, −3, 69 | 384, −5.37 |
| R aIfO | Right postcentral gyrus extending to supramarginal gyrus | 59, −24, 27 | 196, −4.82 |
| R aIfO | Right inferior frontal gyrus extending to insula | 56, 6, 15 | 160, −4.30 |
| R aIfO | Left inferior frontal gyrus extending to insula | −55, 9, 3 | 104, −4.84 |
| Factor 2 | |||
| L aIfO | Right mid-insula extending to anterior insula | 35, 3, −9 | 138, 4.84 |
| R aIfO | Left dorsal anterior cingulate (cluster extends bilaterally) | −7, 0, 33 | 235, 4.44 |
| R aIfO | Right postcentral gyrus extending to supramarginal gyrus | 65, −18, 21 | 166, 4.92 |
| R aIfO | Right inferior frontal gyrus extending to insula | 47, 12, 6 | 163, 4.25 |
| R aIfO | Right medial frontal gyrus | 5, −3, 66 | 156, 4.99 |
| R aIfO | Left inferior frontal gyrus | −55, 9, 0 | 95, 5.40 |
| dACC/msFC | Right precuneus extending to posterior cingulate | 17, −66, 39 | 79, 4.37 |
| Group results: main cortical networks | |||
| FPN | |||
| Psychopathic < nonpsychopathic | |||
| R IPS | Left dorsal anterior cingulate (cluster extends bilaterally) | −1, 12, 39 | 151, −4.37 |
| R IPS | Right precuneus | 8, −57, 57 | 126, −4.48 |
| R IPS | Right insula | 38, 3, −3 | 81, −4.81 |
Significant within-network clusters for psychopathy scores (total PCL-R, Factor 1, and Factor 2) from the regression and between-group comparison analyses. All regression results reported were significant after controlling for age, SUD, race, and IQ (cluster-corrected pFWE = 0.05; Holm–Bonferroni corrected, each p < 0.05).