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. 2015 Apr 15;35(15):6093–6106. doi: 10.1523/JNEUROSCI.3412-14.2015

Table 2.

Signaling pathways enrichment in BN-J versus Lewis or Harlan rat primary RMG cells

Signaling pathways JL JH HL
TGF beta signaling pathway
Matrix metalloproteinases
Kit receptor signaling pathway
Type II interferon signaling (IFNG)
MAPK cascade
p38 MAPK signaling pathway
Signal transduction of S1P
Adipogenesis
Endochondral ossification
Signaling of hepatocyte growth factor receptor
Apoptosis
Senescence and autophagy
p53 signal pathway
Apoptosis modulation by HSP70
FAS pathway and stress induction of HSP regulation
Toll-like receptor signaling pathway
B cell receptor signaling pathway
IL-3 signaling pathway
IL-4 signaling pathway
IL-5 signaling pathway
IL-2 signaling pathway
T cell receptor signaling pathway
IL-6 signaling pathway
IL-7 signaling pathway
IL-9 signaling pathway
Cytokines and inflammatory response
G-protein signaling pathways
Myometrial relaxation and contraction pathways
Small ligand GPCRs
GPCRs
Regulation of actin cytoskeleton
Striated muscle contraction
G13 signaling pathway
Cardiovascular signaling
Integrin-mediated cell adhesion
Focal adhesion
EGFR1 signaling pathway
CDKN1A-EGF-CREB
Hypertrophy model
Calcium regulation in the cardiac cell
Insulin signaling
Osteoclast
Delta-Notch signaling pathway
Wnt signaling pathway
Oxidative stress
Id signaling pathway
PI3K_AKT_NF-κB pathway
EBV LMP1 signaling
TNF-alpha NF-κB signaling pathway
EPO receptor signaling
Renin–angiotensin system
Complement and coagulation cascades
Glutathione metabolism
Urea cycle and metabolism of amino groups
Eicosanoid synthesis

The presented signaling pathways were selected based on significance (p ≤ 0.05) unless stated otherwise. JL, Signaling pathways enriched for genes differentially expressed between Janvier Brown Norway and Lewis rat RMGs; JH, signaling pathways enriched for genes differentially expressed between Janvier and Harlan Brown Norway rat RMGs; HL, signaling pathways enriched for genes differentially expressed between Harlan Brown Norway and Lewis rat RMGs.