Table 2.
Signaling pathways enrichment in BN-J versus Lewis or Harlan rat primary RMG cells
| Signaling pathways | JL | JH | HL |
|---|---|---|---|
| TGF beta signaling pathway | ✓ | ✓ | |
| Matrix metalloproteinases | ✓ | ✓ | |
| Kit receptor signaling pathway | ✓ | ✓ | |
| Type II interferon signaling (IFNG) | ✓ | ✓ | |
| MAPK cascade | ✓ | ✓ | |
| p38 MAPK signaling pathway | ✓ | ||
| Signal transduction of S1P | ✓ | ||
| Adipogenesis | ✓ | ✓ | |
| Endochondral ossification | ✓ | ✓ | |
| Signaling of hepatocyte growth factor receptor | ✓ | ||
| Apoptosis | ✓ | ✓ | |
| Senescence and autophagy | ✓ | ✓ | |
| p53 signal pathway | ✓ | ||
| Apoptosis modulation by HSP70 | ✓ | ||
| FAS pathway and stress induction of HSP regulation | ✓ | ||
| Toll-like receptor signaling pathway | ✓ | ||
| B cell receptor signaling pathway | ✓ | ✓ | |
| IL-3 signaling pathway | ✓ | ✓ | |
| IL-4 signaling pathway | ✓ | ✓ | |
| IL-5 signaling pathway | ✓ | ✓ | |
| IL-2 signaling pathway | ✓ | ||
| T cell receptor signaling pathway | ✓ | ||
| IL-6 signaling pathway | ✓ | ||
| IL-7 signaling pathway | ✓ | ||
| IL-9 signaling pathway | ✓ | ✓ | |
| Cytokines and inflammatory response | ✓ | ||
| G-protein signaling pathways | ✓ | ✓ | |
| Myometrial relaxation and contraction pathways | ✓ | ✓ | ✓ |
| Small ligand GPCRs | ✓ | ✓ | |
| GPCRs | ✓ | ||
| Regulation of actin cytoskeleton | ✓ | ✓ | |
| Striated muscle contraction | ✓ | ✓ | |
| G13 signaling pathway | ✓ | ||
| Cardiovascular signaling | ✓ | ✓ | |
| Integrin-mediated cell adhesion | ✓ | ✓ | ✓ |
| Focal adhesion | ✓ | ||
| EGFR1 signaling pathway | ✓ | ✓ | |
| CDKN1A-EGF-CREB | ✓ | ||
| Hypertrophy model | ✓ | ||
| Calcium regulation in the cardiac cell | ✓ | ✓ | ✓ |
| Insulin signaling | ✓ | ✓ | ✓ |
| Osteoclast | ✓ | ✓ | |
| Delta-Notch signaling pathway | ✓ | ||
| Wnt signaling pathway | ✓ | ||
| Oxidative stress | ✓ | ||
| Id signaling pathway | ✓ | ||
| PI3K_AKT_NF-κB pathway | ✓ | ||
| EBV LMP1 signaling | ✓ | ||
| TNF-alpha NF-κB signaling pathway | ✓ | ||
| EPO receptor signaling | ✓ | ||
| Renin–angiotensin system | ✓ | ||
| Complement and coagulation cascades | ✓ | ✓ | |
| Glutathione metabolism | ✓ | ✓ | |
| Urea cycle and metabolism of amino groups | ✓ | ||
| Eicosanoid synthesis | ✓ |
The presented signaling pathways were selected based on significance (p ≤ 0.05) unless stated otherwise. JL, Signaling pathways enriched for genes differentially expressed between Janvier Brown Norway and Lewis rat RMGs; JH, signaling pathways enriched for genes differentially expressed between Janvier and Harlan Brown Norway rat RMGs; HL, signaling pathways enriched for genes differentially expressed between Harlan Brown Norway and Lewis rat RMGs.