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. 2015 Apr 15;35(15):6153–6164. doi: 10.1523/JNEUROSCI.4571-14.2015

Figure 6.

Figure 6.

RG108 prevents gene expression changes induced by a history of alcohol dependence. A, Figure from Ingenuity Pathway Analysis showing one of the top gene networks that is downregulated by chronic alcohol exposure. This network includes genes involved in calcium release and exocytosis, two processes critical for synaptic transmission. B, Table shows the fold change in gene expression that is obtained by RNA sequencing and qPCR validation. RG108 prevents alcohol-induced decrease expression of syt1 (C), syt2 (D), cacna1a (E), and wnk2 (F). White bars indicate mean values (± SEM) of rats treated with vehicle. Black bars indicate mean values (± SEM) of rats treated with RG108. #p < 0.05, control versus PD rats. *p < 0.05, vehicle versus RG108.