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Increased dendritic excitability in hAPPJ20 mice. A, Representative back-propagating dendritic APs recorded in apical dendrites of CA1 pyramidal neurons in NTG and hAPPJ20 mice. Calibration: 10 mV, 12.5 ms. B, Dendritic AP amplitude was increased by 52 ± 3% in hAPPJ20 mice, indicating increased dendritic excitability (age 3 months; p < 0.0001, t test).
