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Nicotine speeds up the escalation of alcohol self-administration, associated with Fos induction in the nucleus accumbens core. Top, Number of Fos-immunoreactive nuclei per millimeter squared in the NAc-Core. Bottom, Number of Fos-immunoreactive nuclei per millimeter squared in the NAc-Shell. *p < 0.05, different from the other groups; n = 6–8 per group.
