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. 2015 Mar 28;15:46. doi: 10.1186/s12883-015-0305-5

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© Jacobson et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Study design. Patients randomized to 1600 mg QD of study drug titrated from 600 to 1200 to 1600 mg QD over the 2-week titration period and down-titrated from 1600 to 800 mg QD after 3 days of the start of the 1-week taper period. Patients randomized to 1200 mg QD titrated from 400 to 800 mg to 1200 mg QD over the 2-week titration period and down-titrated from 1200 to 600 mg QD after 3 days of start of taper period. Patients started other AEDs during the taper period. AED = antiepileptic drug; QD = once daily; TiP = titration period; TpP = taper period.