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. 2015 Apr 7;15:228. doi: 10.1186/s12885-015-1235-8

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© Barbieri et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Immunohistochemical expression of Ki-67, EGFR, ER-α and CD44 in canine mammary carcinomas. a) Representative staining of a simple tubulopapillary carcinoma, analyzed for the expression of Ki-67 (nuclear staining), EGFR (both nuclear and cytoplasmic immunopositivity), ER-α (distinct nuclear staining) and CD44 (cytoplasmic staining). Antibody localization was done using HRP, with dark brown staining indicating the presence of the specific antigen. Original magnification 40X. Lower panels: negative controls (Neg.) obtained by using mouse (m) or rabbit (r) IgG as primary antibody. b) Distribution of Ki-67 labelling index (LI; 1 = <10%, 2 = 10-50%, 3= > 50% of positive cells/total tumor cells) and IHC scores (0 = negative; 1 = weak positivity; 2 = moderate positivity; 3 = strong positivity) for EGFR, ER-α and CD44 among CMC tissues.