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. 2014 Mar 26;472(12):3728–3739. doi: 10.1007/s11999-014-3580-3

Table 5.

Biomarkers in urine (see Table 1 for abbreviations)

Biomarker Effect Implant Groups compared (test versus control) Test time from implantation (years) Control time from implantation (years) Number of test subjects Number of control subjects Reference
CTX-I None THA Aseptic loosening versus stable implants 8.2 7.8 52 52 [32]
DPYD Elevated THA Aseptic loosening versus stable implants 8.2 7.8 52 52 [32]
DPYD None THA, TKA Aseptic loosening versus stable implants Not specified Not specified 36 33 [24]
DPYD Elevated THA Aseptic loosening versus stable implants 9.6 9.1 50 50 [30]
DPYD None THA Aseptic loosening versus stable implants 12.6 12.6 23 26 [35]
NTX None THA Osteolysis versus stable implants 3.5 6.1 33 127 [34]
NTX None THA Aseptic loosening versus stable implants 8.2 7.8 52 52 [32]
NTX Elevated THA Aseptic loosening versus stable implants 9.6 9.1 50 50 [30]
NTX Elevated THA Osteolysis versus stable implants 8.8 2.4 11 8 [2]
NTX Elevated THA Aseptic loosening versus stable implants 12.6 12.6 23 26 [35]
PYD Elevated THA Aseptic loosening versus stable implants 9.6 9.1 50 50 [30]