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. 2014 Mar 26;472(12):3728–3739. doi: 10.1007/s11999-014-3580-3

Table 7.

Biomarkers in peripheral blood (see Table 1 for abbreviations)

Biomarker Effect Implant Groups compared (test versus control) Test time from implantation (years) Control time from implantation (years) Number of test subjects Number of control subjects Reference
CD14+CD16+ cell number Elevated THA Aseptic loosening versus stable implants 9.7 7.2 43 30 [36]
CD14+CD16+ cell number Elevated THA Aseptic loosening versus stable implants 9.7 2.2 43 16 [36]
CD2+ (%) Elevated THA Aseptic loosening versus stable implants 7 10 26 8 [7]
CD22+ (%) Elevated THA Aseptic loosening versus stable implants 7 10 26 8 [7]
CD25+ (%) Elevated THA Aseptic loosening versus stable implants 7 10 26 8 [7]
CD35+ (%) None THA Aseptic loosening versus stable implants 7 10 26 8 [7]
CD4+ (%) None THA Osteolysis versus stable implants 7 10 26 8 [7]
CD4+ cell number Elevated THA Aseptic loosening versus stable implants 12 4 15 15 [26]
CD8+ (%) None THA Osteolysis versus stable implants 7 10 26 8 [7]
CD8+ cell number Elevated THA Osteolysis versus stable implants 12 4 15 15 [26]
Osteoclastogenesis Elevated THA Aseptic loosening versus stable implants 12 4 15 15 [26]