Table 3.

Univariate and multivariate logistic regression analyses for postoperative complications

Variable	Number of patients	Number of patients with complications (%)	Univariate analysis		Multivariate analysis
			Odds ratio (95% CI)	p value	Odds ratio (95% CI)	p value
Total	5716	381 (6.7%)
Sex
Male	3129 (55%)	233 (7.4%)	Reference		Reference
Female	2587 (45%)	148 (5.7%)	0.75 (0.61–0.93)	0.009	0.79 (0.63–0.98)	0.033
Age
≤ 64 years	3183 (56%)	201 (6.3%)	Reference		Reference
65–79 years	1845 (32%)	112 (6.1%)	0.96 (0.76–1.22)	0.730	0.91 (0.71–1.17)	0.482
≥ 80 years	688 (12%)	68 (9.9%)	1.63 (0.22–2.17)	0.001	1.68 (1.23–2.30)	0.001
Tumor location
Upper extremity	846 (15%)	32 (3.8%)	Reference		Reference
Lower extremity	2698 (47%)	207 (7.7%)	2.11 (1.45–3.09)	< 0.001	1.96 (1.33–2.91)	0.001
Trunk	1718 (30%)	124 (7.2%)	1.98 (1.33–2.95)	0.001	1.65 (1.08–2.50)	0.019
Data not provided	454 (8%)	18 (4.0%)	1.05 (0.58–1.89)	0.871	0.85 (0.45–1.59)	0.611
Charlson Comorbidity Index
2	4206 (74%)	202 (4.8%)	Reference		Reference
3	863 (15%)	87 (10.1%)	2.22 (1.71–2.89)	< 0.001	1.93 (1.47–2.55)	< 0.001
≥ 4	647 (11%)	92 (14.2%)	3.29 (2.53–4.27)	< 0.001	2.85 (2.17–3.74)	< 0.001
Type of surgery
Soft tissue tumor resection	4534 (79%)	288 (6.4%)	Reference		Reference
Bone tumor resection	896 (16%)	73 (8.1%)	1.31 (1.00–1.71)	0.049	0.80 (0.58–1.11)	0.180
Amputation	286 (5%)	20 (7.0%)	1.11 (0.69–1.77)	0.667	0.91 (0.56–1.48)	0.696
Blood transfusion
Yes	1014 (18%)	126 (12.4%)	2.47 (1.98–3.10)	< 0.001	1.79 (1.37–2.34)	< 0.001
Anesthesia time
< 120 minutes	932 (17%)	31 (3.3%)	Reference		Reference
120–240 minutes	2261 (40%)	107 (4.7%)	1.44 (0.96–2.17)	0.077	1.40 (0.93–2.12)	0.107
> 240 minutes	2417 (43%)	234 (9.7%)	3.12 (2.13–4.57)	< 0.001	2.66 (1.78–3.98)	< 0.001
Hospital volume
Low	1741 (31%)	131 (7.5%)	Reference		Reference
Medium	2062 (36%)	122 (5.9%)	0.773 (0.60–0.99)	0.048	0.71 (0.54–0.93)	0.108
High	1913 (33%)	128 (6.7%)	0.88 (0.68–1.14)	0.327	0.89 (0.68–1.16)	0.391