Table 4.

Univariate and multivariate logistic regression analyses for in-hospital mortality

Variable	Number of patients	Number of patients with in-hospital death (%)	Univariate analysis		Multivariate analysis
			Odds ratio (95% CI)	p value	Odds ratio (95% CI)	p value
Total	5716	45 (0.8%)
Sex
Male	3129 (55%)	27 (0.9%)	Reference		Reference
Female	2587 (45%)	18 (0.7%)	0.81 (0.44–1.47)	0.478	0.74 (0.40–1.37)	0.335
Age
≤ 64 years	3183 (56%)	23 (0.7%)	Reference		Reference
65–79 years	1845 (32%)	11 (0.6%)	0.82 (0.40–1.63)	0.599	0.72 (0.34–1.50)	0.376
≥ 80 years	688 (12%)	11 (1.6%)	2.23 (1.08–4.60)	0.030	1.71 (0.78–3.73)	0.178
Tumor location
Upper extremity	846 (15%)	4 (0.5%)	Reference
Lower extremity	2698 (47%)	19 (0.7%)	1.49 (0.51–4.40)	0.467
Trunk	1718 (30%)	19 (1.1%)	2.35 (0.80–6.94)	0.121
Data not provided	454 (8%)	3 (0.7%)	1.40 (0.31–6.28)	0.660
Charlson Comorbidity Index
2	4206 (74%)	19 (0.5%)	Reference		Reference
3	863 (15%)	9 (1.0%)	2.32 (1.05–5.15)	0.038	1.86 (0.82–4.23)	0.137
≥ 4	647 (11%)	17 (2.6%)	5.95 (3.07–11.50)	< 0.001	4.06 (2.05–8.03)	< 0.001
Type of surgery
Soft tissue tumor resection	4534 (79%)	30 (0.7%)	Reference		Reference
Bone tumor resection	896 (16%)	9 (1.0%)	2.52 (0.72–3.22)	0.270	0.65 (0.28–1.47)	0.295
Amputation	286 (5%)	6 (2.1%)	3.22 (1.33–7.79)	0.010	1.57 (0.62–3.97)	0.343
Blood transfusion
Yes	1014 (18%)	31 (3.1%)	10.56 (5.60–19.92)	< 0.001	10.95 (5.59–21.44)	< 0.001
Anesthesia time
< 120 minutes	932 (17%)	6 (0.6%)	Reference
120–240 minutes	2261 (40%)	12 (0.5%)	0.82 (0.31–2.20)	0.699
> 240 minutes	2417 (43%)	24 (1.0%)	1.55 (0.63–3.80)	0.340
Hospital volume
Low	1741 (31%)	20 (1.1%)	Reference		Reference
Medium	2062 (36%)	18 (0.9%)	0.76 (0.40–1.44)	0.396	0.74 (0.38–1.45)	0.384
High	1913 (33%)	7 (0.4%)	0.32 (0.13–0.75)	0.009	0.34 (0.14–0.82)	0.016