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. 2015 Apr 15;6:162. doi: 10.3389/fimmu.2015.00162

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Copyright © 2015 Specht, Ahrens, Blankenstein, Duell, Fietkau, Gaipl, Günther, Gunther, Habl, Hautmann, Hautmann, Huber, Molls, Offner, Rödel, Rödel, Schütz, Combs and Multhoff.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme of the NK cell activation in the clinical phase I trial. NSCLC patients after radiochemotherapy undergo leukapheresis and the immune phenotype (NK cell and T cell markers) is assessed by flow cytometry. Following erythrocyte depletion on a SEPAX system peripheral blood lymphocytes (PBLs) are stimulated ex vivo in a GMP laboratory with TKD/IL-2 for 3–5 days. After measuring of NK activation markers and sterility testing, the activated cells are washed and re-infused (i.v.) in the patient.