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. 2015 Apr 15;6:171. doi: 10.3389/fimmu.2015.00171

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Copyright © 2015 Churlaud, Pitoiset, Jebbawi, Lorenzon, Bellier, Rosenzwajg and Klatzmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of low-dose IL-2 on CD4⁺ Tregs and CD8⁺ Tregs in mice. Eight-week-old female BALB/c mice were injected daily for 5 days with PBS or with 50,000 or 100,000 IU of IL-2, and blood was sampled after the treatment. (A) Relative variations of percentages, CD25 MFI and FOXP3 MFI of CD4⁺ Tregs and CD8⁺ Tregs in blood after treatment (pool of three independent experiments). Individual values and mean ± SEM are shown. (B) Phenotypic activation markers of CD4⁺ Tregs and CD8⁺ Tregs after 5-day course of PBS (PBS) or 50,000 IU of IL-2 (IL-2) (pool of two independent experiments). Individual values and mean ± SEM are shown.