Figure 2.
Inhibition of the classical apoptosis and autophagy pathway by γ-herpesvirus proteins. KSHV vFLIP and K7 target pro-caspase 8 and activated caspase 3 for inhibition, whereas vBcl2 and MHV-68 vMAP antagonize the oligomerization of Bax/Bak and VDAC that release cytochrome c (cyto. c). Additionally, KSHV K7 activates CAML in releasing calcium from the ER to attenuate stress induced apoptosis. Of the classic autophagy pathway, vBcl2 suppresses UVRAG in autophagosome formation. Viral proteins are colored in green.