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. Author manuscript; available in PMC: 2015 Apr 15.

Published in final edited form as: Bioorg Med Chem Lett. 2013 Dec 11;24(2):636–643. doi: 10.1016/j.bmcl.2013.11.077

Scheme 1 — Synthesis of SA and SG. Reagents and Conditions: a) HCl (g), LiCl, CH₃CN, 6 days; b) KSAc, TBAB (Tetrabutylammonium bisulfate), CH₂Cl₂/H₂O, overnight, 50% over 2 steps; c) TosOC₆H₁₂SAc, DEA, DMF, 65%; d) PPh₃, THF/H₂O, 12h; e) (Boc)₂O, TEA, THF, 60% over 2 steps f) MeS-(C=NBoc)NHBoc, HgCl₂, TEA, CH₂Cl₂, 80% over 2 steps; g) MeOH/NaOH (aq), 1 h; h) TFA/DCM (1:1). 90% over two steps for SA and SG, respectively.