Table 1.
IC50 values for the inhibition of soluble NAs and intact virus by the gemini sialoside analogs. The influenza strains used in these studies were Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).
| Name | Structure | Virus | NA from Virus | ||
|---|---|---|---|---|---|
| H3N2 (μM) | H1N1 (μM) | H5N1 (μM) | H3N2 (μM) | ||
| SA |
|
64±14 | 56±6 | 127±29 | 178±20 |
| C6-SA |
|
11.6±3.5 | 9.9±1.8 | 20±5 | 32±5 |
| C12-SA |
|
15±9 | 11±1 | 31±7 | 40±1 |
| TetraEG-SA |
|
11±5 | 9.8±2.4 | 28±3 | 39±14 |
| PentaEG-SA |
|
21±3 | 36±4 | 64±14 | 178±20 |
| HexaEG-SA |
|
33±15 | 45±1 | 85±12 | 216±56 |
| SG |
|
0.55±0.02 | 0.8±0.1 | 0.1±0.02 | 1±0.1 |
| C6-SG |
|
0.25±0.05 | 0.26±0.03 | 0.2±0.02 | 4.2±1.2 |
| C12-SG |
|
0.5±0.3 | 0.8±0.06 | 0.73±0.03 | 12±2 |
| TetraEG-SG |
|
1.78±1.3 | 2.4±0.4 | 2.5±0.1 | 10±1 |
| PentaEG-SA |
|
1±0.6 | 1.2±0.2 | 1.1±0.1 | 10±2 |
| HexaEG-SA |
|
0.5±0.2 | 0.9±0.1 | 0.57±0.06 | 11±2 |
| Zanamivir® |
|
~0.001 | ~0.01 | ~0.04 | ~0.04 |
| Oseltamivir ® |
|
~0.008 | ~0.01 | ~0.05 | ~0.05 |