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. Author manuscript; available in PMC: 2015 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Dec 11;24(2):636–643. doi: 10.1016/j.bmcl.2013.11.077

Table 2.

IC50 values of influenza strains by the gemini sialosides based on 50% decrease in plaque size. The strains used in these studies were Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).

Name Structure Virus
H3N2 (μM) H1N1 (μM)
SA graphic file with name nihms548246t15.jpg 10–100 >100
C6-SA graphic file with name nihms548246t16.jpg 1–10 100
C12-SA graphic file with name nihms548246t17.jpg 1–10 100
TetraEG-SA graphic file with name nihms548246t18.jpg 1–10 100
PentaEG-SA graphic file with name nihms548246t19.jpg 1–10 100
HexaEG-SA graphic file with name nihms548246t20.jpg 1–10 100
SG graphic file with name nihms548246t21.jpg 1–10 10
C6-SG graphic file with name nihms548246t22.jpg 0.01–0.1 10
C12-SG graphic file with name nihms548246t23.jpg 0.1 1.0
TetraEG-SG graphic file with name nihms548246t24.jpg 0.1 1.0
PentaEG-SG graphic file with name nihms548246t25.jpg .01–0.1 1.0
HexaEG-SG graphic file with name nihms548246t26.jpg 0.1–1.0 1.0
Zanamivir® graphic file with name nihms548246t27.jpg 0.001 0.01
Oseltamivir ® graphic file with name nihms548246t28.jpg 0.001–0.01 0.001–0.01