Screening Performance and Costs of Different Strategies in Prenatal Screening for Trisomy 21

. 2015 Mar;75(3):244–250. doi: 10.1055/s-0035-1545885

Table 6 Test quality and cost of screening for trisomy 21 using FTS followed by cffDNA in the intermediate-risk group.

False positive rate (n,%)Detection rate (n,%)Cost (€)		Threshold value used to define the high risk group
False positive rate (n,%)Detection rate (n,%)Cost (€)		1 : 10	1 : 50	1 : 100
Costs are calculated based on FTS, cffDNA and invasive diagnostics:FTS: 675 332 pregnancies × €150 pluscffDNA [number of pregnancies in the intermediate-risk group] × €500 plusinvasive diagnostics [number of screen-positive cases] × €1 000
Threshold value used to define the low-risk group	1 : 1 000	8 296 (1.2)1 729 (96.7)180 275 800	18 740 (2.8)1 732 (96.9)185 198 300	29 835 (4.4)1 733 (96.9)190 532 800
Threshold value used to define the low-risk group	1 : 5 000	14 471 (2.1)1 773 (99.2)286 201 800	24 914 (3.7)1 776 (99.3)291 123 300	36 009 (5.3)1 777 (99.4)296 457 300