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. 2015 Mar;75(3):251–254. doi: 10.1055/s-0035-1545869

Table 2 Analysis of antiphospholipid antibodies in women without and with long-term HC use (2008–2013).

Group 1 Group 2 Group 3 Subgroup 4 from Group 3 p-value
NS – not significantGroup 1 – not on HC; Subgroup 4 (HC use of between 10 years and 20 years)
N 220 221 749 213
Mean age (years) 28.7 27.8 31.4 35.6 NS
Presence of antiphospholipid antibodies against: 56 (25 %) 95 (43 %) 588 (78.5 %) 189 (89 %) 0.001

  • Cardiolipin

 IgG 3 (1.4 %) 4 (1.8 %) 18 (2.4 %) 5 (2.3 %) NS
IgM 2 (0.9 %) 3 (1.3 %) 0 (0 %) 5 (2.3 %) NS

  • Ph-inositol

 IgG 54 (24.5 %) 58 (26.2 %) 273 (36.4 %) 212 (99.5 %) 0.001
IgM 2 (0.9 %) 1 (0.4 %) 5 (0.6 %) 5 (2.0 %) NS

  • Ph-serine

 IgG 19 (8.6 %) 21 (9.5 %) 321 (42.8 %) 208 (98.0 %) 0.001
IgM 0 (0 %) 4 (1.8 %) 8 (1.0 %) 6 (2.8 %) NS

  • Ph-glycerol

 IgG 11 (5.0 %) 8 (3.6 %) 57 (7.60 %) 41 (19.0 %) NS
IgM 0 (0 %) 4 (1.8 %) 12 (1.6 %) 8 (4.0 %) NS

  • Ph-ethanolamine

 IgG 12 (5.4 %) 8 (3.6 %) 61 (8.1 %) 51 (24.0 %) 0.01
IgM 1 (0.4 %) 2 (0.9 %) 16 (2.0 %) 9 (4.2 %) NS

  • β2-GPI

 IgG 5 (2.3 %) 20 (9.0 %) 39 (5.2 %) 29 (13.6 %) 0.01
IgA 0 (0 %) 1 (0.4 %) 10 (1.3 %) 3 (1.4 %) NS

  • Phosphatidic acid

 IgG 16 (7.2 %) 8 (3.6 %) 60 (8.0 %) 23 (10.8 %) NS
IgM 0 (0 %) 0 (0 %) 0 (0 %) 3 (1.4 %) NS

  • Annexin V

 IgG 5 (2.3 %) 9 (4 %) 37 (4.9 %) 32 (15.0 %) 0.01