Table 1.
Exposure dose, onset of fever and time to death in individual NHPs
| Animal ID | Target Dose (CFU) | Inhaled Dose (CFU) | Average Day of Fever Onseta | Time of Death (Days) | Manner of Death |
|---|---|---|---|---|---|
| AGM 1 | 10 | 11 | No fever | NA | Survived |
| AGM 2 | 100 | 40 | 4 | 14 | Euthanized |
| AGM 3 | 100 | 216 | 4 | 8 | Found Dead |
| AGM 4 | 1,000 | 271 | 3 | 6 | Euthanized |
| AGM 5 | 10,000 | 10,908 | 3 | 6 | Euthanized |
| CM 1 | 10 | 20 | No fever | NA | Survived |
| CM 2 | 100 | 32 | 4 | 22 | Euthanized |
| CM 3 | 100 | 186 | NAb | 10 | Found Dead |
| CM 4 | 1,000 | 332 | 4 | 10 | Euthanized |
| CM 5 | 1,000 | 801 | 3 | 9 | Euthanized |
| CM 6 | 10,000 | 11,298 | 2 | 6 | Euthanized |
| RM 1 | 1,000 | 377 | 3 | NA | Survived |
| RM 2 | 3,000 | 2,693 | 2 | NA | Survived |
| RM 3 | 10,000 | 11,211 | 3 | NA | Survived |
| RM 4 | 10,000 | 15,593 | 3 | NA | Survived |
| RM 5 | 100,000 | 276,667 | 3 | 6 | Euthanized |
a
Fever defined as an elevation of body temperature >1.5°C over baseline values, as established on study day −1, for at least 6 consecutive hours for each individual.
b
Telemetry for this animal was failed , therefore data was not available.
NA: Not applicable