Complexity
|
Organism |
Xenograft |
Organ/Tissue |
Multicellular aggregate |
Cellular |
Substrate
|
NA |
(Orthotopic/Heterothopic) |
Synthetic Fibers (e.g. PCL) |
Biological Gels (e.g. Matrigel, Collagen, Laminin rich gels) |
Plastic or Glass |
Cell Type
|
NA |
Homotypic/Heterotypic |
Homotypic/Heterotypic |
Homotypic/Heterotypic |
Homotypic |
Tumor Niche
|
Physiologic |
Chimeric: Animal/Human |
Yes |
Limited |
No |
Biology Studies
|
Limited |
Yes (Costly) |
Yes (Specialized techniques) |
Limited |
No |
Preclinical Drug Testing (correlation with human trials)
|
NA |
High (Low throughput) |
Intermediate (Intermediate throughput) |
Intermediate (High throughput) |
Low (High throughput) |
Biomarker development
|
Yes |
Yes |
Unknown |
No |
No |
Personalized Medicine (CLIA-certified)
|
Yes |
Yes |
No |
No |
No |