Table 4.
Reclassification of Participants in the External-Validation Data Set with the Use of the Creatinine–Cystatin C Equation versus the Creatinine Equation for Estimated GFR.*
| Total Group | Subgroup with Measured GFR <60 ml/min/1.73 m2 |
Subgroup with Measured GFR ≥60 ml/min/1.73 m2 |
Overall NRI (95% CI)† | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Range of eGFRcr | No. of Participants | Total Reclassified | No. of Participants | Correctly Reclassified: eGFRcr-cys <60 vs. eGFRcr ≥60 |
Incorrectly Reclassified: eGFRcr-cys ≥60 vs. eGFRcr <60 |
Net Difference | No. of Participants | Correctly Reclassified: eGFRcr-cys ≥60 vs. eGFRcr <60 |
Incorrectly Reclassified: eGFRcr-cys <60 vs. eGFRcr ≥60 |
Net Difference | |
| ml/min/1.73 m2 | no. (%) | percentage points | no. (%) | percentage points | % | ||||||
| 6–155 | 1119 | 62 (5.5) | 533 | 17 (3.2) | 8 (1.5) | 1.7 | 586 | 28 (4.8) | 9 (1.5) | 3.2 | 4.9 (2.2–7.7) |
|
| |||||||||||
| 30–89 | 569 | 61 (10.7) | 302 | 16 (5.3) | 8 (2.6) | 2.7 | 267 | 28 (10.5) | 9 (3.4) | 7.1 | 9.8 (4.3–15.3) |
|
| |||||||||||
| 45–74 | 277 | 58 (20.9) | 124 | 15 (12.1) | 8 (6.5) | 5.7 | 153 | 28 (18.3) | 7 (4.6) | 13.7 | 19.4 (8.7–30.1) |
|
| |||||||||||
| 60–74 | 111 | 22 (19.8) | 21 | 15 (71.4) | NA | NA | 90 | NA | 7 (7.8) | NA | NA |
|
| |||||||||||
| 45–59 | 166 | 36 (21.7) | 103 | NA | 8 (7.8) | NA | 63 | 28 (44.4) | NA | NA | NA |
*
Unless otherwise stated, values in cells are numbers of participants with percentages in parentheses. The term eGFRcr denotes estimated GFR from creatinine equation, eGFRcr-cys estimated GFR from creatinine–cystatin C equation, and NA not applicable.
†
Values for the net reclassification index (NRI) range from -200 to 200 and are the total percentage of patients who have been reclassified. P<0.001 for all comparisons. CI denotes confidence interval.