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. Author manuscript; available in PMC: 2016 Feb 3.
Published in final edited form as: Cell Metab. 2015 Feb 3;21(2):237–248. doi: 10.1016/j.cmet.2014.12.021

Figure 3. Mediator Subunits Alter Systemic Metabolism in a Muscle-Specific Manner.

Figure 3

Perturbations of MED13 and MED30 in the heart alter metabolism. Overexpression of MED13 in the heart causes leanness, and loss of MED13 in the heart increases susceptibility of obesity and diabetes. Loss-of-function mutations in MED30 lead to altered substrate availability, heart failure, and death. Loss of MED1 in muscle causes a fast-to-slow muscle fiber type switch, which enhances insulin sensitivity and protects against obesity.