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. Author manuscript; available in PMC: 2015 Apr 15.
Published in final edited form as: Free Radic Biol Med. 2010 Jul 13;49(6):1119–1128. doi: 10.1016/j.freeradbiomed.2010.06.030

Fig. 6.

Fig. 6

Decreasing NOX4 expression attenuates AP-ICAM induction of increased GSH and GCL activity. (A) The decrease in NOX4 mRNA expression after NOX4 siRNA administration is shown. (B) The effect of targeted NOX4 knockdown on GSH production in response to vehicle, AP, or AP-ICAM peptide treatment (normalized to vehicle). (C) The effect of targeted NOX4 knockdown on GCL activity in response to vehicle, AP, or AP-ICAM peptide treatment (normalized to vehicle). n=5; #p<0.001, *p<0.01; experiments performed in quadruplicate.