Table 3.
Toxicity profiles
| No. of episodes (%) |
||||||
|---|---|---|---|---|---|---|
| GP |
XP |
|||||
| Grade 1-2 | Grade 3-4 | Total | Grade 1-2 | Grade 3-4 | Total | |
| Hematologic | ||||||
| Anemia | 61 (33.9) | 17 (9.4) | 78 (43.3) | 35 (18.6) | 5 (2.7) | 40 (21.3) |
| Neutropenia | 25 (13.9) | 27 (15) | 52 (28.9) | 21 (11.2) | 27 (14.4) | 48 (25.5) |
| Thrombocytopenia | 48 (26.7) | 19 (10.6) | 67 (37.2) | 40 (21.3) | 17 (9) | 57 (30.3) |
| Non-hematologic | ||||||
| Nausea | 11 (6.1) | 5 (2.8) | 16 (8.9) | 7 (3.7) | 7 (3.7) | 14 (7.4) |
| Vomiting | 7 (3.9) | 6 (3.3) | 13 (7.2) | 4 (2.1) | 3 (1.6) | 7 (3.7) |
| Anorexia | 4 (2.2) | 3 (1.7) | 7 (3.9) | 8 (4.3) | 5 (2.7) | 13 (6.9) |
| Asthenia | 12 (6.7) | 4 (2.2) | 16 (8.9) | 4 (2.1) | 13 (6.9) | 17 (9) |
| Stomatitis | 1 (0.6) | 0 | 1 (0.6) | 10 (5.3) | 7 (3.7) | 17 (9) |
| Diarrhea | 0 | 0 | 0 | 5 (2.7) | 1 (0.5) | 6 (3.2) |
| Neuropathy | 2 (1.1) | 2 (1.1) | 4 (2.2) | 4 (2.1) | 4 (2.1) | 8 (4.3) |
| Nephropathy | 2 (1.1) | 1 (0.6) | 3 (1.7) | 4 (2.1) | 4 (2.1) | 8 (4.3) |
| Hand-foot syndrome | 0 | 0 | 0 | 15 (8) | 6 (3.2) | 21 (11.2) |
| Infection | 0 | 2 (1.1) | 2 (1.1) | 0 | 0 | 0 |
GP, gemcitabine-cisplatin; XP, capecitabine-cisplatin.