TABLE 3.
Multivariate Analyses (Adjusted for Age, Study, Weight, Ethnicity, Cytogenetic-Defined Risk Group, and Presenting White Blood Cell Count)
| Characteristic | OS From Study Entry |
EFS From Study Entry |
TRM From Study Entry |
RR From End of Course 1 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Age, 16-20 y | 148 | 1.28 | 1.00-1.65 | .053 | 1.19 | 0.95-1.50 | .136 | 2.3 | 1.59-3.33 | <.001 | 0.80 | 0.57-1.13 | .206 |
| Underweight | 120 | 1.26 | 0.95-1.67 | .111 | 1.16 | 0.89-1.50 | .265 | 1.50 | 0.92-2.44 | .100 | 1.12 | 0.78-1.61 | .550 |
| Overweight | 131 | 1.56 | 1.21-2.03 | <.001 | 1.36 | 1.08-1.73 | .011 | 2.18 | 1.42-3.36 | <.001 | 1.00 | 0.70-1.42 | .995 |
| Black/Hispanic | 262 | 1.46 | 1.19-1.79 | <.001 | 1.33 | 1.11-1.61 | .003 | 1.23 | 0.85-1.78 | .279 | 1.38 | 1.06-1.79 | .016 |
| WBC count (>100,000) | 155 | 1.45 | 1.14-1.84 | .003 | 1.56 | 1.25-1.94 | <.001 | 1.17 | 0.75-1.81 | .496 | 1.45 | 1.05-2.01 | .024 |
| Low (t(8;21 or inv(16)) | 261 | 0.45 | 0.35-0.58 | <.001 | 0.52 | 0.42-0.64 | <.001 | 1.10 | 0.77-1.59 | .591 | 0.46 | 0.34-0.61 | <.001 |
| High (Mono 7 or -5/5q-) | 41 | 1.85 | 1.26-2.72 | .016 | 1.83 | 1.27-2.65 | .001 | 1.18 | 0.55-2.56 | .671 | 1.29 | 0.67-2.50 | .440 |
Abbreviations: CI, confidence interval; EFS, event-free survival; HR, hazard ratio; OS, overall survival; TRM, treatment-related mortality; RR, risk of relapse; WBC, white blood cell count.