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. 2015 May;117:20–26. doi: 10.1016/j.antiviral.2015.02.005

Fig. 2.

Fig. 2

Epoxide based inhibitors of the NS2 autoprotease. (A) JFH1 NS2–3 refolding reactions were treated with indicated concentrations of 1 alongside controls and NS3-FLAG proteolysis product (arrowhead) was quantified by western blot. EC50 = 92 μM. (B) Identical treatment of JFH1 NS2–3 refolding reactions with 2. EC50 = >300 μM. (C) J4 NS2–3 refolding reactions treated as in A. EC50 = 79 μM. Chemical structures are shown in Table 1.