Table 6. Upstream regulators in the RFI network obtained by Ingenuity Pathway Analysis.
| Upstream Regulator | Molecule type a | p-value of overlap b | Target molecules in RFI network c |
|---|---|---|---|
| TP53 | transcription regulator | 2.08 x 10–09 | 95 |
| TGFB1 | growth factor | 5.60 x 10–08 | 106 |
| ERG | transcription regulator | 1.66 x 10–06 | 22 |
| Sos | group | 4.41 x 10–06 | 23 |
| PKD1 | ion channel | 1.22 x 10–05 | 20 |
| TGFB3 | growth factor | 1.44 x 10–05 | 14 |
| HNRNPA2B1 | other | 3.65 x 10–05 | 17 |
| PADI2 | enzyme | 5.91 x 10–05 | 3 |
| RB1 | transcription regulator | 6.65 x 10–05 | 24 |
| ZNF217 | transcription regulator | 1.02 x 10–04 | 11 |
| TBX5 | transcription regulator | 1.15 x 10–04 | 10 |
| ERBB2 | kinase | 2.01 x 10–04 | 43 |
| ER | group | 2.35 x 10–04 | 21 |
| REST | transcription regulator | 2.71 x 10–04 | 13 |
| NFE2L2 | transcription regulator | 3.14 x 10–04 | 30 |
| DMD | other | 4.19 x 10–04 | 17 |
| DAB1 | other | 5.57 x 10–04 | 3 |
| SETDB1 | enzyme | 7.60 x 10–04 | 6 |
| FOS | transcription regulator | 9.81 x 10–04 | 34 |
| WNT3A | cytokine | 1.04 x 10–03 | 18 |
a the molecule class to which the respective upstream regulator belongs
b p-value of significance as determined from the number of feed efficiency genes that overlap with the respective upstream regulator
c number of RFI network genes targeted by the respective upstream regulator
RFI: residual feed intake.