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. 2015 Jan 22;4(2):282–300. doi: 10.1002/mbo3.237

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© 2015 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Gemomic context of the lipB/A operon/genes in the selected γ-proteobacteria. Blue arrows represent the lipA genes that encode the lipoic acid synthase catalyzing the last committed reaction of lipoic acid biosynthesis pathway, whereas green arrows indicate the octanoyl-protein ligase-encoding genes (lipB).The gray arrow upstream of the lipB gene refers to the ybeD gene of unknown function. In some cases, the tatE gene (Sec-independent protein translocase) downstream of lipA is shown with yellow arrow. In the four species (Escherichia coli, Enterobacter sp. 638, Klebsiella pneumoniae, and Salmonella typhimurium LT2), the ybeF gene encoding an LysR-type transcription factor (in orange) is located between lipA and lipB. The predicted CRP-binding palindromes are highlighted with dots (red dots represent the experimentally verified sites, whereas the gray ones are not experimentally validated). CRP, cAMP-receptor protein.