Figure 8. The balance between g_leak and the efficacy of virtual nicotinic EPSPs.

A, family of EPSPs elicited by virtual synaptic conductances of increasing strength (90–650% threshold-g_syn) in a dissociated superior cervical ganglion neuron. B–D, the same virtual EPSPs were elicited after addition of 3, 10 and 20 nS g_leak. This resulted in a systematic reduction in the efficacy of EPSPs. In the face of the non-depolarizing leaks, it took more g_syn to trigger an action potential.