Table 1. Relationship between T cell subset density and clinicopathological features in the training set of CRC.

		Tumor center						Invasion front
	N (%)	CD8	p value	CD45RO	p value	FOXP3	p value	CD8	p value	CD45RO	p value	FOXP3	p value
Age
<65	119 (54.6)	120.0	0.886	204.0	0.910	54.0	0.267	138.1	0.798	177.5	0.385	57.4	0.927
≥65	99 (45.4)	119.8		199.1		47.1		140.9		177.9		60.0
Gender
Male	133 (61.0)	126.3	0.371	209.3	0.875	56.4	0.071	135.9	0.627	178.2	0.740	62.5	0.087
Female	85 (39.0)	109.3		189.7		42.2		142.1		177.0		52.5
pTNM stage
I or II	123 (56.4)	128.8	0.758	214.9	0.199	47.1	0.232	154.3	0.037	212.3	0.012	57.2	0.630
III or IV	95 (43.6)	112.8		191.6		53.8		125.6		150.5		59.6
Lymphatic invasion
Yes	107 (49.1)	113.2	0.337	183.1	0.116	50.7	0.877	117.4	0.125	148.4	0.074	54.3	0.314
No	111 (50.9)	126.1		219.5		51.0		158.1		205.4		62.7
Distant metastasis
Yes	44 (20.2)	101.5	0.133	199.0	0.208	51.9	0.965	88.1	0.002	104.4	< 0.001	55.7	0.938
No	174 (79.8)	124.5		202.6		50.6		150.1		195.6		59.3
MSI status
Positive	8 (4.0)	130.5	0.084	154.8	0.913	46.7	0.704	241.5	0.617	226.9	0.438	56.9	0.898
Negative	190 (96.0)	119.0		205.6		51.4		137.1		178.4		5.9
CIMP status
Positive	13 (6.0)	111.7	0.843	263.4	0.227	68.2	0.130	105.2	0.249	164.5	0.540	56.7	0.927
Negative	205 (94.0)	120.5		198.1		49.7		140.5		178.5		58.7
Tumor location
Colon	158 (72.5)	122.1	0.588	195.7	0.155	49.2	0.110	144.3	0.794	179.0	0.146	56.2	0.033
Rectum	60 (27.5)	114.1		218.3		55.2		122.2		174.2		65.0

T cell subset densities represent median values for labelled cells per mm²; MSI: microsatellite instability; CIMP: CpG island methylator phenotype