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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Am J Surg Pathol. 2015 May;39(5):581–591. doi: 10.1097/PAS.0000000000000387

Figure 2. Disruption of ALK identified by FISH A.

Figure 2

Unbalanced rearrangement of the ALK gene, with preservation of the 3′ signal (red) and the remaining intact ALK gene (1 juxtaposed green and orange signal). B. Balanced rearrangement of the ALK gene with separated orange and green signals compared to the remaining intact locus. C. Amplification of the 3′ oncogenic signal (1 or 2 fusion signals + numerous clustered orange signals).