Table 1.
Comparison of clinicopathologic characteristics
| Grade Concordant (Mitotic G2/Ki67 G2) PanNETs (n=53) | Grade Discordant (Mitotic G2/Ki67 G3) PanNETs (n=19) | Poorly Differentiated NECs (n=43) | P value | |
|---|---|---|---|---|
|
| ||||
| Mean Age (years) (range) | 55 (29–80) | 54 (25–84) | 59 (21–82) | 0.16 |
|
| ||||
| Sex (M:F) | 1.7 | 1.7 | 1.3 | 0.88 |
|
| ||||
| Syndromic | Multiple Endocrine Neoplasia 1 (n=2) Von Hippel-Lindau (n=1) |
Von Hippel-Lindau (n=1) | 0 | - |
|
| ||||
| Functional | Gastrinoma (n=1) Insulinoma (n=1) |
Ectopic ACTH (n=1) | 0 | - |
|
| ||||
| Location (head vs body or tail) | 25/28 | 6/13 | 26/14 | 0.04 |
|
| ||||
| Median tumor size (cm) (range) | 4.3 (1.2–17) | 4.5 (2–15) | 4.1 (2–18) | 0.20 |
|
| ||||
| Vascular invasion | 44/50 (88%) | 16/17 (94%) | 23/29 (79%) | 0.28 |
|
| ||||
| Perineural invasion | 29/44 (66%) | 8/16 (50%) | 20/28 (71%) | 0.35 |
|
| ||||
| pT | - | |||
| pT1 | 4 (8%) | 0 (0%) | 1 (2.5%) | |
| pT2 | 4 (8%) | 1 (6%) | 2 (5%) | |
| pT3 | 42 (84%) | 16 (94%) | 35 (92%) | |
|
| ||||
| LN metastasis | 27/52 (52%) | 8/17 (47%) | 34/40 (85%) | 0.79* 0.004** |
|
| ||||
| Distant metastasis | 25/36 (69%) | 10/15 (67%) | 11/25 (44%) | 1.0* 0.12** |
*
Grade-discordant PanNETs vs grade-concordant PanNETs
**
Grade-discordant PanNETs vs poorly differentiated NECs