. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2015 Mar 28;103(4):260–268. doi: 10.1002/bdra.23353

Table 3.

Follow-up of Isolated Second-Trimester Ultrasonographic Soft Markers for Down Syndrome Beyond a Targeted Ultrasonogram

Soft marker	Other considerations and follow-up
Choroid plexus cyst	None^*
Echogenic cardiac focus	None^*
Nuchal fold thickening	Genetic counseling
Absent/hypoplastic nasal bone	Genetic counseling
Pyelectasis ≥4 mm up to 20 weeks	32-week ultrasonography to assess kidneys and urinary collecting system
Echogenic bowel	Genetic counseling 32-week ultrasonography to assess growth and bowel
Shortened long bone	Consider third-trimester ultrasonography to assess growth^*

If isolated finding and aneuploidy screening reveals low-risk