Skip to main content
. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: J Pathol. 2015 Feb 19;236(1):30–40. doi: 10.1002/path.4508

Figure 1. PTEN is reduced in podocytes of mice and patients with diabetic nephropathy.

Figure 1

A: Immunoblots of PTEN and nephrin in isolated glomeruli from Wild-type (Wt) and db/db mice. B: confocal immunofluorescence microscopy of isolated glomeruli stained for PTEN and nephrin. PTEN expression is decreased in podocytes (nephrin positive cells, arrows) of db/db mice. C: immunoblot of PTEN in podocytes isolated from db/db mice. PTEN expression is significantly decreased. D: confocal immunofluorescence microscopy of glomeruli from healthy controls and patients with DN. PTEN (green signal) is decreased in podocytes (arrows) of patients with DN.