Table 1.

Protein sequence homology alignment between mouse and human catechol-O-methyl transferase (COMT). Met (M) residues are in bold and ¹⁵⁸ Val of the human COMT is both in bold and underlined

Mouse	20	RHLGWGLVAIGWFEFVQQPVHNLLMGGTKEQRILRHVQQHAKPGDPQSVLEAIDTYCSEK RH GWGL IGW EF+QP+HNLLMG TKEQRIL HV QHA+PG+QSVLEAIDTYC+K	79
Human	27	RHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQK	86
Mouse	80	EWAMNVGDAKGQIMDAVIREYRPSLVLELGAYCGYSAVRMARLLPPGARLLTMEINPDYA EWAMNVGD KG+I+DAVI+E++PS++LELGAYCGYSAVRMARLL PGARL+T+EINPD A	139
Human	87	EWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCA	146
Mouse	140	AITQQMLDFAGLQDKVSILIGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEE AITQ+M+DFAG++DKV++++GASQD+IPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEE	199
Human	147	AITQRMVDFAG VKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEE	206
Mouse	200	CGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAVYQGPG CGLLRKGTVLLADNVI PG PDFLA+VRGSS FECTHY S+LEY+VVDGLEKA+Y+GPG	259
Human	207	CGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPG	266
Mouse	260	SS S	261
Human	267	SE	268