Table 3.
Age-, sex-adjusted associations of VDR Tru9I genotypes and risk for incident sporadic colorectal adenomas according to adenoma characteristics, MAP Study, 1994-1997
| Adenoma characteristics |
Tru9I genotypes |
|||
|
UU |
Uu+uu |
|||
| Cases/controls (n) | OR1/95%CI2 | Cases/controls (n) | OR/95%CI | |
| Multiplicity | ||||
| 1 | 85/171 | 1.00 | 20/49 | 0.88 (0.48-1.60) |
| >1 | 59/171 | 1.00 | 7/49 | 0.51 (0.21-1.24) |
| Shape | ||||
| Sessile | 51/171 | 1.00 | 5/49 | 0.36 (0.13-0.97) |
| Pedunculated | 97/171 | 1.00 | 22/49 | 0.93 (0.51-1.68) |
| Size (cm)3 | ||||
| <1.0 | 111/171 | 1.00 | 24/49 | 0.84 (0.47-1.49) |
| ≥1.0 | 33/171 | 1.00 | 3/49 | 0.37 (0.11-1.28) |
| Dysplasia4 | ||||
| Mild | 73/171 | 1.00 | 15/49 | 0.79 (0.41-1.53) |
| ≥Moderate | 71/171 | 1.00 | 12/49 | 0.68 (0.33-1.41) |
| Morphology5 | ||||
| Tubular | 131/171 | 1.00 | 27/49 | 0.80 (0.46-1.38) |
| Any villous | 13/171 | 1.00 | 0/49 | NA6 |
1
Odds ratio;
2
95% confidence interval; 3greatest diameter of largest adenoma; 4dysplasia in adenoma with greatest degree of dysplasia; 5if multiple adenomas, classified as “Any villous” if any adenoma villous or tubulovillous; 6not available.