Table 4.
Multivariate-adjusted1 joint and combined associations of VDR Tru9I genotypes and various risk factors for colorectal neoplasms and risk for incident sporadic colorectal adenomas, MAP study, 1994-1997
|
UU |
Uu+uu |
|||||
| Cases (n) | Controls (n) | OR2/95%CI3 | Cases (n) | Controls (n) | OR/95%CI | |
| Age (yr) | ||||||
| ≤57 | 58 | 83 | 1 | 12 | 31 | 0.60 (0.26-1.37) |
| >57 | 86 | 89 | 1.41 (0.86-2.31) | 15 | 18 | 1.09 (0.46-2.56) |
| Sex | ||||||
| Male | 85 | 60 | 1 | 15 | 16 | 0.65 (0.28-1.53) |
| Female | 59 | 112 | 0.51 (0.30-0.85) | 12 | 33 | 0.38 (0.17-0.88) |
| Current smoker | ||||||
| No | 35 | 77 | 1 | 6 | 25 | 0.39 (0.13-1.23) |
| Yes | 105 | 94 | 1.84 (1.07-3.17) | 20 | 24 | 1.56 (0.69-3.53) |
| Current drinker | ||||||
| No | 63 | 99 | 1 | 13 | 26 | 0.96 (0.44-2.08) |
| Yes | 77 | 71 | 1.65 (1.01-2.69) | 12 | 22 | 0.90 (0.39-2.06) |
| NSAID4 use | ||||||
| No | 118 | 117 | 1 | 21 | 38 | 0.64 (0.34-1.23) |
| Yes | 23 | 54 | 0.48 (0.26-0.86) | 5 | 11 | 0.38 (0.12-1.25) |
| Total calcium intake5 | ||||||
| Lower | 92 | 84 | 1 | 13 | 23 | 0.53 (0.23-1.20) |
| Higher | 49 | 86 | 0.53 (0.32-0.87) | 14 | 26 | 0.52 (0.23-1.14) |
| Total vitamin D intake6 | ||||||
| Lower | 76 | 83 | 1 | 14 | 25 | 0.59 (0.26-1.33) |
| Higher | 65 | 87 | 0.78 (0.48-1.27) | 13 | 24 | 0.60 (0.27-1.38) |
1Adjusted for age, sex, total energy intake, history of colon cancer in a first degree relative, nonsteroidal anti-inflammatory drug use, current smoking status, and total calcium and alcohol intakes; 2odds ratio; 395% confidence interval; 4nonsteroidal anti-inflammatory drug; 5sex-specific median calcium intakes for males 701.3 mg/d, for females 754.1 mg/d; 6sex-specific median vitamin D intakes for males 257.2 IU/d, for females 229.7 IU/d.